<ul class="flex-container">
  <li><a href="#">Index</a></li>
  <li><a href="#">About me</a></li>
  <li><a href="#">Contact</a></li>
</ul>

.flex-container > * {
  padding: 0.3em;
  list-style-type: none;
  text-shadow: 0 0 2px red;
  float: left;
}

@supports (display: flex) {
  .flex-container > * {
    text-shadow: 0 0 2px blue;
    float: none;
  }

  .flex-container {
    display: flex;
  }
}